The Use of Modafinil in the Intensive Care Unit

In this small case series, the authors address a several issues related to sleep deprivation in the ICU, namely fatigue, depression and excessive daytime somnolence. The investigators sought to determine the use of modafinil, a psycho-stimulant, could improve ICU outcomes by treating some of these conditions. They discovered that through the use of modafinil 200mg each morning patient had greater wakefulness, were able to participate in rehab more and got more sleep at night. This study will need to be repeated on a larger scale to help determine if modafinil can have a true impact on ICU outcomes.