The Relationship Between Hippocampal Volume and Cognition in Patients With Chronic Primary Insomnia

In this study the authors found that hippocampal volume (HV) in primary insomniacs (PI) was negatively correlated with the duration of insomnia and the arousal index. PIs exhibited significantly impaired attention, frontal lobe function, and memory, and their verbal and nonverbal memory scores were positively correlated with HV. These findings suggest that chronic sleep deprivation associated with insomnia impairs memory and frontal lobe function, and that insomnia duration and poor sleep quality contribute to a bilateral reduction in HV.