The Prospective Association of Objectively Measured Sleep and Cerebral White Matter Microstructure in Middle-Aged and Older Persons

“Middle-aged and older persons with more wake after sleep onset, lower sleep efficiency and corresponding shorter sleep duration have altered microstructure in the projection and association tracts, in the cingulum, and in the anterior forceps of corpus callosum. If future studies confirm our findings, poor sleep could be considered as a risk factor for microstructural alterations of white matter in the aging brain.”