The prevention of delirium in elderly with obstructive sleep apnea (PODESA) study: protocol for a multi-centre prospective randomized, controlled trial

Multicenter randomized controlled trial will enroll 634 elderly patients undergoing elective lower joint replacement surgery. Patients identified with OSA will be randomized to Auto-titrating continuous airway pressure (APAP) applied during sleep for 72h postoperatively or to control group without APAP. Delirium will be evaluated by using the Confusion assessment method in all patients for 72 hours postoperatively. Since delirium is associated with increased morbidity and mortality, findings could potentially inform best practices to improve surgical outcome and increase safety in the elderly patients with OSA.

https://www.ncbi.nlm.nih.gov/pubmed/29298664