Sleep Fragmentation Promotes NADPH Oxidase 2-Mediated Adipose Tissue Inflammation Leading to Insulin Resistance in Mice

These studies imply that sleep fragmentation, a frequent occurrence in many disorders and more specifically in sleep apnea, is a potent inducer of insulin resistance via activation of oxidative stress and inflammatory pathways.

http://www.ncbi.nlm.nih.gov/pubmed/23897221