Sedation-Analgesia with Propofol and Remifentanil: Concentrations Required to Avoid Gag Reflex in Upper Gastrointestinal Endoscopy

The work presented by Borrat et al wants to define safe sedation and analgesia guidelines in this case for upper gastrointestinal endoscopy. One of the most stressful moments for the patient is introduction of the endoscopy tube through the mouth and pharynx. Using a sequential statistical approach the concetrations associated with a probability of 0.5 or 0.9 of avoding gag response are estimated and could be used as a starting point for any combination of sedation and analgesia in this situation.