Intermittent Hypoxia Causes Inflammation and Injury to Human Adult Cardiac Myocytes

The authors compared the cellular responses of cultured human adult cardiac myocytes exposed to intermittent hypoxia and different conditions of continuous hypoxia and normoxia. Intermittent and constant severe hypoxia, but not constant mild hypoxia or normoxia, induced inflammation and cell injury in the myocytes as evidenced by lower cell count and viability, and greater cytokine secretion. The greatest cell injury occurred with intermittent severe hypoxia.