Independent Association Between Nocturnal Intermittent Hypoxemia and Metabolic Dyslipidemia

In a sample of 2,018 patients who underwent measurement of fasting lipid levels and nocturnal recording for assessment of obstructive sleep apnea, total cholesterol and LDL were not associated with the oxygen desaturation index. However, nocturnal intermittent hypoxemia and OSA severity were associated with higher triglycerides and lower HDL-C, independent of confounders. This may provide a mechanism through which OSA is associated with cardiovascular risk.