Effects of Sleep and Wake on Astrocytes:
clues from Molecular and Ultrastructural Studies

This paper investigates the relationship between sleep/wake states and astrocyte maintenance of the dendritic spine niche. In the awake or chronic sleep restriction states, synaptic associations are maintained indicating a role for the astrocyte in preserving synapses. This work provides a mechanistic glimpse of how the sleep state may be responsible for synaptic pruning important for long-term potentiation or long-term depression in memory consolidation.