Posted in
Literature Updates, Sleep
Posted:
January 1, 2015
Authors: Kumar AR, Guilleminault C, Certal V
Published: J Laryngol Otol. 2014 Dec 29:1-9.
In this systematic review and meta-analysis, outcomes of adults with obstructive sleep apnea treated with nasopharyngeal airway stenting devices were studied. Of 573 potential studies, 29 were retrieved for detailed evaluation and 16 met the study criteria. Only case series or case studies were identified. Short-term benefits were identified in polysomnographic indices such as the apnea-hypopnea index and oxygen saturation, especially in postoperative patients. However, long-term data with respect to patient tolerance and adherence was lacking. Future research should be directed towards designing randomized controlled trials, comparing these devices to other interventions such as CPAP, with extensive follow up and long-term clinical outcomes
http://www.ncbi.nlm.nih.gov/pubmed/25544266
Posted in
Literature Updates, Sleep
Posted:
January 1, 2015
Authors: Bano M, Chiaromanni F, Corrias M
Published: Front Neurol. 2014 Dec 11;5:267.
In this prospective cohort study, 118 consecutive inpatients were screened and 99 patients were enrolled to assess sleep quality in a group of medical inpatients, in relation to environmental factors, and the switch to daylight-saving time. Thirty three percentage of the patients reported one/more sleepless nights. Patients who slept near the window were exposed to more light in the morning and tended to sleep better. Noise levels were higher than recommended for care units. Future research is needed to evaluate interventions designed to improve sleep quality for inpatients in medical and surgical wards.
http://www.ncbi.nlm.nih.gov/pubmed/25566173
Posted in
Basic Research, Literature Updates
Posted:
January 1, 2015
Authors: Phillips DJ, Savenkova MI, Karatsoreos IN
Published: Brain Behav Immun. 2014 Dec 24.
Mice chronically maintained on a shortened day schedule (20 hours – 10 hours light : 10 hours dark) as a model of circadian disruption have no total sleep deprivation but lose the nocturnal-diurnal oscillation in REM and NREM percentage present in control animals. When exposed to an in vivo LPS challenge experimental animals demonstrate altered peripheral immune responses notably the chemokine MCP-1, and altered hippocampal cytokine mRNA expression. This work intimates the importance of intact circadian rhythm in generating immune responses and maintaining normal sleep quality.
http://www.ncbi.nlm.nih.gov/pubmed/25542734
Posted in
Basic Research, Literature Updates
Posted:
January 1, 2015
Authors: Stoyan Dimitrov, Luciana Besedovsky, Jan Born, Tanja Lange
Published: Brain Behav Immun. 2014 Dec 10. pii: S0889-1591(14)00561-3.
This study looked at the effect of sleep deprivation on serum, and released TNF-α from monocytes in human subjects. Sleep deprivation resulted in a blunted oscillation of TNF-α release in-vivo, decreased oscillation of circulating monocytes during the study period and was associated with decreased TNF-α production from LPS stimulated monocytes ex-vivo. Correlation analysis in the normal sleep group points towards a regulatory association of circulating hormones including cortisol, norepinephrine and prolactin. This study is objectively supportive of a widely held belief that normal sleep is necessary for a robust immune response to an innate immune challenge.
http://www.ncbi.nlm.nih.gov/pubmed/25500219
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Schwengel DA, Dalesio NM, Stierer TL.
Published: Anesthesiol Clin. 2014 Mar;32(1):237-61.
Adenotonsillectomy is the most commonly used treatment option for OSAS in childhood, but efforts are underway to identify medical treatment options
http://www.ncbi.nlm.nih.gov/pubmed/24491659
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Tolisano AM, Bager JM.
Published: Laryngoscope. 2014 Jun;124(6):E250-4.
The majority of outcomes favored the defendant. Type of injury did not predict outcome. Failure to recognize complications and delay in diagnosis strongly predicted a verdict in favor of the plaintiff.
http://www.ncbi.nlm.nih.gov/pubmed/24347364
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Coté CJ, Posner KL, Domino KB.
Published: Anesth Analg. 2014 Jun;118(6):1276-83.
A validated pediatric-specific risk assessment scoring system is needed to assist with identifying children at risk for OSA who are not appropriate to be cared for on an outpatient basis.
http://www.ncbi.nlm.nih.gov/pubmed/23842193
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Nath A, Emani J, Suskind DL, Baroody FM.
Published: JAMA Otolaryngol Head Neck Surg. 2013 Oct;139(10):1002-8.
In a subgroup of children younger than 3 years with OSA, we found a high rate of residual OSA after T&A. Predictors of residual disease include severity of preoperative OSA as determined by PSG result. Postoperative PSGs might be indicated in these patients.
http://www.ncbi.nlm.nih.gov/pubmed/24030757
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Wood JM, Cho M, Carney AS.
Published: J Laryngol Otol. 2014 Jan;128 Suppl 1:S3-7.
In children, subtotal tonsillectomy is associated with fewer post-operative complications whilst having a comparable effect in improving sleep disordered breathing, compared with total tonsillectomy.
http://www.ncbi.nlm.nih.gov/pubmed/24280113
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2015
Authors: Volsky PG, Woughter MA, Beydoun HA, Derkay CS, Baldassari CM.
Published: Otolaryngol Head Neck Surg. 2014 Jan;150(1):126-32.
Quality of life significantly improves in children with mild OSA after adenotonsillectomy. In children with mild OSA who are observed, QOL improvements at early follow-up are less pronounced, but significant improvements in QOL are evident after 8 months.
http://www.ncbi.nlm.nih.gov/pubmed/24170659
