Clinical Adult Literature Updates from July 2019

Obstructive Sleep Apnea and Longitudinal Alzheimer’s Disease Biomarker Changes

“OSA appears to accelerate increases in amyloid deposition, CSF T-tau and P-tau levels over time, both in cognitive normal and mild cognitive impaired individuals. Sleep fragmentation, intermittent hypoxia, and intrathoracic pressure swings from OSA are likely candidate mechanisms. (…) No significant variations in the biomarkers changes over time were seen in the Alzheimer disease group.”

Effect of Trendelenburg and Lower Body Positive Pressure on Neck Fluid Distribution

In this prospective study, the authors include 22 patients. The aim of this study was to achieve the impact of vascular and extravascular fluid to the total accumulation of neck fluid volume. The authors conclude that sustained elevation in neck fluid volume while supine is likely due to the extravascular fluid. This data could improve the relationship between rostral fluid load and upper-airway narrowing.