Sleep Literature Updates from June 2018

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

Perioperative myocardial injury is transcriptionally orchestrated by the circadian clock in patients undergoing aortic valve replacement, and Rev-Erbα antagonism seems to be a pharmacological strategy for cardioprotection. Afternoon surgery might provide perioperative myocardial protection and lead to improved patient outcomes compared with morning surgery.

https://www.ncbi.nlm.nih.gov/pubmed/29107324

Altered resting-state hippocampal and caudate functional networks in patients with obstructive sleep apnea

The compromised hippocampal-cortical functional connectivity in OSA may underlie depression and anxious mood levels in OSA, while impaired caudate-cortical FC may indicate deficits in reward processing and cognition. These findings provide insights into the neural mechanisms underlying the comorbidity of mood and cognitive deficits in OSA.”

https://www.ncbi.nlm.nih.gov/pubmed/29749715