Posted in
Basic Research, Literature Updates
Posted:
January 1, 2013
Authors: Akinnusi M, Jaoude P, Kufel T, El-Solh AA
Contributors: Susana Vacas
Published: Sleep Breath. 2012 Dec 14
Obstructive sleep apnea has been linked to chronic inflammation and cardiovascular diseases. This work demonstrated that OSA is associated with enhanced expression and signaling events downstream of TLR2 and TLR4 in circulating monocytes. These observations were mitigated by CPAP therapy, which suggest that TLR2 and TLR4 activation may be involved as a signaling mechanism in immune-mediated progression of atherosclerosis in OSA.
http://www.ncbi.nlm.nih.gov/pubmed/23239459
Posted in
Basic Research, Literature Updates
Posted:
January 1, 2013
Authors: Gettys GC, Liu F, Kimlin E, Baghdoyan HA, Lydic R
Contributors: Susana Vacas
Published: Anesthesiology. 2012 Dec 19
Adenosine has several actions depending on the receptors targeted. This work supports the interpretation that an adenosinergic-cholinergic interaction within the –tailed hypothesis that adenosine A1 receptors in the pontine comprises one neurochemical mechanism underlying the wakefulness stimulus for breathing.
http://www.ncbi.nlm.nih.gov/pubmed/23263018
Posted in
Basic Research, Literature Updates
Posted:
January 1, 2013
Authors: Moore JT, Chen J, Han B, Meng QC, Veasey SC, Beck SG, Kelz MB
Contributors: Susana Vacas
Published: Curr Biol. 2012 Oct 23. pii: S0960-9822(12)01007-X.
This work demonstrated that volatile anesthetics are capable of directly activating endogenous sleep-promoting networks by activating VLPO nucleus.
http://www.ncbi.nlm.nih.gov/pubmed/23103189
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Kim J
Contributors: Kimmo Murto
Published: Front Biosci (Elite Ed). 2012 Jun 1;4:2410–22.
In this paper, we will critically review the available evidence linking OSAS to systemic inflammation in children using CRP levels as the reporter biomarker.
http://www.ncbi.nlm.nih.gov/pubmed/22652648
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: DiFeo N, Meltzer LJ, Beck SE, Karamessinis LR, Cornaglia MA, Traylor J, Samuel J, Gallagher PR, Radcliffe J, Beris H, Menello MK, Marcus CL
Contributors: Kimmo Murto
Published: J Clin Sleep Med. 2012 Jun 15;8(3):279–86. doi: 10.5664/jcsm.1914.
PAP adherence in children and adolescents is related primarily to family and demographic factors rather than severity of apnea or measures of psychosocial functioning. Further research is needed to determine the relative contributions of maternal education, socioeconomic status and cultural beliefs to PAP adherence in children, in order to develop better adherence programs.
http://www.ncbi.nlm.nih.gov/pubmed/22701385
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: Di Francesco R, Monteiro R, Paulo ML, Buranello F
Contributors: Kimmo Murto
Published: Imamura R. Sleep Med. 2012 Jun;13(6):616–20. doi: 10.1016/j.sleep.2011.12.011. Epub 2012 Mar 28.
Craniofacialmorphology may influence the severity of sleep apnea in boys but not in girls.
http://www.ncbi.nlm.nih.gov/pubmed/22459090
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: Lee SH, Choi JH, Park IH, Lee SH, Kim TH, Lee HM, Park HK, Thomas RJ, Shin C, Yun CH
Contributors: Kimmo Murto
Published: Laryngoscope. 2012 Sep;122(9):2115–21. doi: 10.1002/lary.23356. Epub 2012 Jun 27.
The aim of this study was to demonstrate postoperative changes in sleepquality in children with obstructive sleep apnea (OSA), using both conventional sleep staging and electrocardiogram-based cardiopulmonary coupling (CPC) analysis. In pediatric OSA, postoperative improvement of sleepquality is more readily discernible by CPC analysis than EEG-based sleep staging.
http://www.ncbi.nlm.nih.gov/pubmed/22740041
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: Goldstein NA, Stefanov DG, Graw-Panzer KD, Fahmy SA, Fishkin S, Jackson A, Sarhis JS, Weedon J
Contributors: Kimmo Murto
Published: Laryngoscope. 2012 Sep;122(9):2096–104. doi: 10.1002/lary.23455. Epub 2012 Aug 13.
They concluded “The CAS-15 proved useful in an office setting and correctly diagnosed 72% of referred children when compared to polysomnography. It correlated well with external measures and demonstrated a good response to clinical change.”
http://www.ncbi.nlm.nih.gov/pubmed?term=22890967
Posted in
Clinical Pediatric, Literature Updates
Posted:
January 1, 2013
Authors: Certal V, Catumbela E, Winck JC, Azevedo I, Teixeira-Pinto A, Costa-Pereira A
Contributors: Kimmo Murto
Published: Laryngoscope. 2012 Sep;122(9):2105–14.doi:10.1002/lary.23465.Epub 2012 Aug 9.
They concluded “Neither single nor combined symptoms and signs have satisfactory performance in predicting pediatric OSA. Alternative diagnostic models are necessary to improve the accuracy.”
http://www.ncbi.nlm.nih.gov/pubmed/22886768
Posted in
ICU, Literature Updates
Posted:
January 1, 2013
Authors: Gehlbach BK, Chapotot F, Leproult R, Whitmore H, Poston J, Pohlman M, Miller A, Pohlman AS, Nedeltcheva A, Jacobsen JH, Hall JB, Van Cauter E
Contributors: Rondall Lane
Published: Sleep. 2012 Aug 1;35(8):1105–14
The authors of this study sought to determine if sleep regulation as regulated by circadian and homeostatic processes remains organized in patients being mechanically ventilated. The authors discovered that circadian rhythm pacemaker function appears to be “free running” in most patients evaluated.
https://www.ncbi.nlm.nih.gov/pubmed/22851806
