Associations Between Change in Sleep Duration and Inflammation: Findings on C-Reactive Protein and Interleukin 6 in the Whitehall II Study

In a sample of 5,003 midlife men and women, shorter sleep (< 5 hours per night) was associated with higher levels of CRP and IL-6 and in longitudinal analyses, a greater increase in sleep duration was associated with a significant 5-year increase in CRP and IL-6.