Altered Structural Brain Network Resulting from White Matter Injury in Obstructive Sleep Apnea

“For similar degrees of sleep apnea, the severity, diversity (mood, executive function, attention), and clustering of clinical symptoms remain largely unexplained. Using DTI to assess brain tissue integrity and brain network properties in OSA, we observed markers of WM injury and abnormalities in the structural brain network. Such changes provide a basis for altered functional connectivity and clinical symptom diversity. In addition, we found that the structural brain network was influenced by WM injury. Our findings provide new insights into the causes of functional deficits in sleep apnea syndromes.”