Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys

In a randomized cross-over design, 21 healthy normal weight males underwent 3 consecutive nights of sleep restriction (4 hr/night) and long sleep (9 hr/night). Pre– and post-prandial glucose, insulin and other metabolic markers were obtained. Fasting insulin, fasting C-peptide and post-prandial C-peptide were higher in sleep restriction condition than long sleep. HOMA-IR was also higher under sleep restriction.