Acute Kynurenine Challenge Disrupts Sleep-Wake Architecture and Impairs Contextual Memory in Adult Rats

Tryptophan metabolism via the kynurenine pathway may represent a key molecular link between sleep loss and cognitive dysfunction.

The results of this study  introduce kynurenine pathway metabolism and formation of metabolite kynurenic acid  as a novel molecular target contributing to sleep disruptions and cognitive impairments.

https://www.ncbi.nlm.nih.gov/pubmed/29029302