Impact of Obstructive Sleep Apnea Syndrome on Cognition in Early Postmenopausal Women

Early postmenopausal women who were not on hormone replacement therapy completed a REDCap survey on demographics and risk factor, Berlin questionnaire and Mail-in Cognitive Function Screening Instrument (MCFSI) score to assess cognitive impairment. Early postmenopausal women at high risk for OSAS reported more cognitive impairment than those at low risk for OSAS.

Chronic Widespread Musculoskeletal Pain in Patients with Obstructive Sleep Apnea Syndrome and the Relationship Between Sleep Disorder and Pain Level, Quality of Life, and Disability

In this study, the authors examined the prevalence of chronic widespread musculoskeletal pain (CWP) in patients who were undergoing PSG for suspected OSAS. They found that 41 of the 74 patients (55%) had CWP. Female patients had a greater risk of CWP than male patients. Female OSAS patients with CWP had higher pain levels, greater disability levels, higher BMIs and a lower quality of life.

The Effects of Continuous Positive Airway Pressure on Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Surgery: A Systematic Review and Meta-Analysis

This review suggests that there is “no significant difference in the postoperative adverse events between CPAP and no-CPAP treatment. Patients using CPAP had significantly lower postoperative AHI and a trend toward shorter LOS. There may be potential benefits in the use of CPAP during the perioperative period”

Preoperative Sleep Disruption and Postoperative Delirium

Delirium and sleep disruption are both common in the older patients who are hospitalized. Sleep disruption, including changes in sleep patterns and architecture, and decreased quality of sleep are commonly observed in older subjects. In a preliminary study, we monitored sleep in 50 patients (mean age 66 ± 11 years) with wrist actigraphy for 3 days before and 3 days after surgery. Postoperative delirium was measured using the Confusion Assessment Method. By actigraphy, the preoperative sleep for patients who ultimately developed postoperative delirium showed disruption beginning 2 days before surgery. The incidence of postoperative delirium observed during any of the 3 postoperative days was 14%. For the 7 patients with postoperative delirium, wake after sleep onset (WASO) as a percentage of total sleep time was significantly higher (44% ± 22%) during the night before surgery compared to the patients without delirium (21% ± 20%, p = 0.012). Patients with WASO < 10% did not experience postoperative delirium. We concluded in this pilot study that sleep disruption was more severe in the days just before surgery in the patients who experienced postoperative delirium. Our novel finding of sleep disruption beginning before surgery provides important guidance for clinical assessment and interventions to improve sleep before surgery. Specifically, future work should target the etiology of nocturnal wake time in the period immediately before the planned surgery.