GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking but Not the Sleep-Wake Switch or Propofol-Induced Loss of Consciousness

This work provides more questions to the role of propofol in entering sleep circuitry. It suggests that a primary function of GABAA receptor-mediated inhibition is to dampen vigilant arousal and it does not appear to influence the loss of consciousness associated with either natural sleep or propofol-induced anesthesia.