The Role of CPAP Treatment in Elderly Patients with Moderate Obstructive Sleep Apnea. A Multicenter Randomised Controlled Trial

In this open-label, randomized, multicenter study, 143 elderly patients (70 years or older) with moderate OSA were randomized to receive either CPAP (n=73) or no CPAP (n=72) for 3 months. The primary endpoint was the Epworth Sleepiness Scale (ESS), and secondary endpoints were quality of life, sleep-related symptoms, presence of anxiety or depression, office-based blood pressure, and some neurocognitive tests. They found that the CPAP group had better ESS scores, some sleep-related symptoms, and some dimensions of the quality of life questionnaire. However, there was no effect on the neurocognitive tests, including anxiety and depression or blood pressure levels. There was a positive correlation between the effects of CPAP and the improvement in EES values and quality of life domains.