This quality improvement project prospectively screened neurosurgical patients for OSA using the STOP-Bang questionnaire and explored its relationship with respiratory complications. Scores of 5 or greater were considered as high risk and less than 5 as low risk for moderate-to-severe OSA. Postoperative respiratory complications were compared between both OSA groups. Perioperative staff and patient education included an OSA care protocol using STOP-Bang screening. Results showed that the OSA care protocol decreased the risk for postoperative respiratory complications, demonstrating that education is essential to confer safer perioperative outcomes.