Non-steady State Modeling of the Ventilatory Depressant Effect of Remifentanil in Awake Patients Experiencing Moderate-to-severe Obstructive Sleep Apnea.

The aim of this prospective study was to evaluate the sensibility of moderate-to-severe OSA patients to remifentanil-induced ventilatory depression. These patients were matched with control patients. Interestingly, the results demonstrate that OSA patients were not influence by opioids in terms of ventilatory depression. To the best of our knowledge, this was the first time that such results were highlighted.