Melatonin Secretion Pattern in Critically Ill Patients: A Pilot Descriptive Study

Authors: Boyko Y, Holst R, Jennum P, Oerding H, Nikolic M, Toft P.

In this pilot descriptive study, melatonin secretion pattern in conscious, critically ill patients on mechanical ventilation was found to follow a diurnal but phase-delayed curve. Remifentanil infusion did not affect melatonin secretion but was associated with lower risk of atypical sleep.