Hypnotics’ Association With Mortality or Cancer: A Matched Cohort Study

This study sought to estimate the mortality risks associated with specific currently popular hypnotics in a matched cohort design of 10,529 pts who received hypnotic prescriptions and 23,676 matched controls that did not and followed for an average of 2.5 years. They used proportional hazards regression models and also tried to estimate the cancer risks associated with hypnotics. Data were adjusted for age, gender, smoking, body mass index, ethnicity, marital status, alcohol use and prior cancer. They found that pts prescribed any hypnotic had substantially elevated hazards of dying (mostly cardiovascular diseases) compared to those prescribed no hypnotics. Further, those in the upper third of regular hypnotic use had a significant elevation of incident cancer; HR=1.35 and were not attributable to pre-existing disease. The authors concluded that even when prescribed