Effects of continuous positive airway pressure on cardiovascular biomarkers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials

This meta-analysis sought to quantify the effects of CPAP on cardiovascular biomarkers (high sensitivity CRP, IL-6, TNF-alpha, augmentation index, pulse wave velocity and flow-mediated dilatiationand to establish predictors of response to CPAP. The authors included 15 RCTs with 1090 patients in the meta-analysis. They found that CPAP improves inflammatory markers hs-CRP, arterial stiffness marker Alx, and endothelial function marker FMD. The authors concluded that these biomarkers may provide information about response to treatment with CPAP.