Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Collu MA(1), Esteller E(2), Lipari F (3), Hasper R(4), Mulas D(4), Diaz MA(5), Dwivedi
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: RC(6) Int J Pediatr Otorhinolaryngol.2018 May;108:113-119. doi: 10.1016/j.ijporl.2018.02.038. Epub 2018 Mar 6.
Adenotonsillar hypertrophy is the most common cause but not the only cause for OSAS in children. This study looked at the role of DISE in 3 different categories of pediatric OSAS, “conventional”, “disproportional” and “persistent” OSAS. All subjects had preoperative confirmatory polysomnograms. The authors observed that, in otherwise healthy children, DISE changed the surgical plan more frequently in children with “disproportional” and “persistent” OSAS. Additional procedures included functional endoscopic sinus surgery (FESS) for polyp removal and pharyngoplasty for lateral pharyngeal wall collapse correction.
https://www.ncbi.nlm.nih.gov/pubmed/?term=29605338
Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Hinkle J(1), Connolly HV(2), Adams HR(3), Lande MB(4).
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: J Am Soc Hypertens. 2018 Mar;12(3):204-210. doi: 10.1016/j.jash.2017.12.010. Epub 2018 Jan 3.
In summary, habitual snoring is common in children referred for elevated BP, and those with severe OSA are at higher risk of significantly increased BP.
https://www.ncbi.nlm.nih.gov/pubmed/29373256
Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Macey PM, Kheirandish-Gozal L, Prasad JP, Ma RA, Kumar R, Philby MF, Gozal D
Contributors: Susana Vacas
Published: Front Neurol. 2018 Jan 22;9:4
Changes in cortical thickness are present in children with OSA and likely indicate disruption to neural developmental processes, including maturational patterns of cortical volume increases and synaptic pruning. Regions with thicker cortices may reflect inflammation or astrocyte activation. Both the thinning and thickening associated with OSA in children may contribute to the cognitive and behavioral dysfunction frequently found in the condition.
https://www.ncbi.nlm.nih.gov/pubmed/29403430
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Zeng G, Teng Y, Zhu J, Zhu D, Yang B, Hu L, Chen M, Fu X.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: Medicine (Baltimore). 2018 Jan;97(4):e9680
“Stenosis of the nasopalatine pharyngeal cavity in children with adenoidal hypertrophy was greatest at the end-expiration phase during sleep. The end-expiratory Sa/Snp obtained by a combination of MRI and respiratory gating technology has potential as an important imaging index for diagnosing and evaluating severity in pediatric OSAHS.”
https://www.ncbi.nlm.nih.gov/pubmed/29369187
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Dirain CO, Silva RC, Collins WO, Antonelli PJ.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: J Int Adv Otol. 2017 Dec;13(3):333-339.
“Microbes are present on all adenoid specimens, though the microbial profile differs between recurrent AOM and OSA. The clinical significance of these differences remains to be determined.”
https://www.ncbi.nlm.nih.gov/pubmed/29360088
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Narang I, McCrindle BW, Manlhiot C, Lu Z, Al-Saleh S, Birken CS, Hamilton J.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: Sleep Breath. 2018 Jan 22.
“Intermittent nocturnal hypoxia rather than the OAHI was associated with metabolic risk in obese youth after adjusting for WHtR. Measures of abdominal adiposity such as WHtR should be considered in future studies that evaluate the impact of OSA on metabolic health.”
https://www.ncbi.nlm.nih.gov/pubmed/29357088See comment in PubMed Commons below
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Idris G, Galland B, Robertson CJ, Gray A, Farella M.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: J Dent. 2018 Jan 18.
“Wearing an Active MAS overnight, over a short period can be beneficial for SDB children, resulting in a clinically relevant reduction of supine AHI.”
https://www.ncbi.nlm.nih.gov/pubmed/29357293
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: Am J Respir Crit Care Med. 2018 Jan 11.
“The risk for OSA could be stratified according to controller gain, plant gain, cardiorespiratory coupling and gestational age. These findings could guide a personalized care to children at risk for OSA.”
https://www.ncbi.nlm.nih.gov/pubmed/29323933
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Canora A, Franzese A, Mozzillo E, Fattorusso V, Bocchino M, Sanduzzi A.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: Eur J Pediatr. 2018 Jan 9.
“OSA was the predominant sleep-related disorder in our PWS patients, not associated with age or obesity, and appeared more severe than previously reported. Further studies addressing the underlying mechanisms are necessary in larger study populations to better design the most appropriate clinical approach.” What is Known: • Sleep-related patterns and their management are very limited in patients with Prader-Willi syndrome. What is New: • Severe obstructive sleep apnoea is the most frequent sleep-related disorder in our case series.
https://www.ncbi.nlm.nih.gov/pubmed/29318372
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 27, 2018
Authors: Chen VC, Yang YH, Kuo TY, Huang KY, Huang YC, Lee Y, McIntyre RS, Huang YS, Hsu CY.
Contributors: Rajeev Subramanyam, Denis Jablonka
Published: Pediatr Infect Dis J. 2018 Jan 8.
Children with severe EV infection (i.e. requiring hospitalization) carry a significantly higher risk of developing OSA, particularly in those with allergic rhinitis. As pediatric obstructive sleep apnea is a treatable sleep disorder, we emphasize regular follow-up and early detection in children with EV infection.
https://www.ncbi.nlm.nih.gov/pubmed/29315158
