Posted in
Clinical Pediatric, Literature Updates
Posted:
July 25, 2019
Authors: Chutima Kraikriangsri, Anant Khositseth, Teeradej Kuptanon
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: Sleep Med. 2019 Feb;54:159-163.
“P-wave dispersion (PWD) as defined by the difference between the duration of maximum and minimum p-waves has been used to screen for the presence of OSAS in adults. This study looks at the utility of this tool for OSAS screening in children. The authors obtained ECGs from 77 children with documented OSAS by PSG and 44 controls. A cutoff of 26.5 ms provided 89.6% sensitivity and 61.4% specificity. PWD was significantly higher in children with severe OSA even when the authors adjusted for the presence of obesity.”
https://www.ncbi.nlm.nih.gov/pubmed/30580188
Posted in
Clinical Pediatric, Literature Updates
Posted:
July 25, 2019
Authors: E.Esteller, J.C.Villatoro, A.Agüero, E.Matiñó, R.Lopez, A.Aristimuño, V.Nuñez, M.A.Díaz-Herrera
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: Int J Pediatr Otorhinolaryngol. 2019 Feb 6;120:118-122
“Drug-induced sleep endoscopy (DISE) can be considered in children with persistent OSAS despite adenotonsillectomy. The authors described sleep-related outcomes in 20 children a year after DISE directed surgery (e.g., turbinate reductions, pharyngoplasty, lingual tonsillectomy, and tonsillectomy revisions). All children demonstrated an improvement in their sleep breathing parameters. Five children had complete resolution of OSAS whereas 15 continue to have persistent OSAS but in the mild range”.
https://www.ncbi.nlm.nih.gov/pubmed/30776569
Posted in
Clinical Pediatric, Literature Updates
Posted:
July 25, 2019
Authors: Ting Chen, MSPH , Mary E. Hughes, PhD , Hongjian Wang, PhD , Guoying Wang, MD , Xiumei Hong, PhD , Li Liu, PhD , Yuelong Ji, PhD , Colleen Pearson, BA , Shenghui Li, MD, PhD , Lingxin Hao, PhD , and Xiaobin Wang, MD, ScD
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: J Pediatr. 2019 Jun 25. pii: S0022-3476(19)30670-5
“In this study, the authors tested associations between pre and perinatal and early childhood factors and the risk of childhood OSAS from a cohort of 2867 mother-child pairs already enrolled in the Boston Birth Cohort Study. Children conceived by in-vitro fertilization, premature deliveries due to trauma were some of the exclusions. This secondary analysis study demonstrated strong associations between childhood OSAS and prematurity/low birth weight, maternal obesity/diabetes, childhood obesity, and elevated early childhood leptin levels. “
https://www.ncbi.nlm.nih.gov/pubmed/31253409
Posted in
Clinical Pediatric, Literature Updates
Posted:
December 28, 2018
Authors: Chi-Chih Lai, MD, FACS, Pei-Wen Lin, MD , Hsin-Ching Lin, MD, FACS, Michael Friedman, MD, FACS, Hsueh-Wen Chang, PhD, Anna M. Salapatas, MS, Meng-Chih Lin, MD and Pa-Chun Wang, MD
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: Ann Otol Rhinol Laryngol.2018 Sep;127(9):608-613. doi: 10.1177/0003489418781961. Epub 2018 Jun 21.
This is a retrospective study in from Taiwan in children with documented OSAS by PSG. The authors sought to determine which clinical signs would be most significant when building a logistic regression model for pediatric AHI. They propose a formula that takes the child BMI, the degree of snoring and nasal obstruction to estimate the AHI. The authors cautioned that their findings warrant further validation in different world regions and in different race populations.
https://www.ncbi.nlm.nih.gov/pubmed/30550132
Posted in
Clinical Pediatric, Literature Updates
Posted:
December 28, 2018
Authors: George Κ. Mousailidisa , Vasileios A. Lachanasa, Afroditi Vasdekib , Emmanuel I. Alexopoulosc , Athanasios G. Kaditisd , Efthymia Petinakib , Nikolaos Balatsose , John G. Bizakisa , Charalampos E. Skoulakisa
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: Int J Pediatr Otorhinolaryngol. 2018 Dec;115:149-152. doi: 10.1016/j.ijporl.2018.10.002. Epub 2018 Oct 4.
In this study, the authors measure urinary levels of Cysteine Leukotrienes (CysLT) in children with documented severe OSAS by PSG before and after adenotonsillectomy. CysLT has been previously implicated in the development of adenotonsillar hypertrophy and pediatric OSAS. Children with residual OSAS were excluded. A total of 24 children were included for analysis. The authors suggest further studies in order to determine CysLT as valid biomarker for the presence of OSA in children.
https://www.ncbi.nlm.nih.gov/pubmed/?term=30368376
Posted in
Clinical Pediatric, Literature Updates
Posted:
September 20, 2018
Authors: Kishan M. Thadikonda, Amber D. Schaffer, Amanda L. Stapleton
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: Int J Pediatr Otorhinolaryngol. 2018 Mar;106:46-49.
Adenoidectomy-alone is a surgical option for young children given its low risk compared to adenotonsillectomy. This retrospective cohort study from Pittsburgh, Pennsylvania, addresses specific outcomes such as the rate of further surgical revisions and or tonsillectomy in children younger than three years of age. Thirty-five percent of children identified in this cohort (n=148) required additional surgical interventions within approximately 24 months of follow-up after adenoidectomy-alone. The most common procedure was adenotonsillectomy. Risk factors associated with residual symptoms following surgery were gastroesophageal reflux and tonsil size.
https://www.ncbi.nlm.nih.gov/pubmed/29447890
Posted in
Clinical Pediatric, Literature Updates
Posted:
September 20, 2018
Authors: Sarah Selvadurai Jason T Maynes Conor McDonnell Sharon L Cushing Evan J Propst Armando Lorenzo Andrew Lim Lisa J Meltzer Zihang Lu Richard L Horner Indra Narang
Contributors: Susana Vacas
Published: Sleep. 2018 Aug 1;41(8).
In this study, general anesthesia did not result in disturbed sleep or associated negative behavioral changes in otherwise healthy children undergoing elective surgeries of low complexity. Physicians can advise parents that a child’s surgery and associated generalanesthetic exposure may not result in significant changes in postoperative sleep patterns.
https://www.ncbi.nlm.nih.gov/pubmed/29741674
Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Collu MA(1), Esteller E(2), Lipari F (3), Hasper R(4), Mulas D(4), Diaz MA(5), Dwivedi
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: RC(6) Int J Pediatr Otorhinolaryngol.2018 May;108:113-119. doi: 10.1016/j.ijporl.2018.02.038. Epub 2018 Mar 6.
Adenotonsillar hypertrophy is the most common cause but not the only cause for OSAS in children. This study looked at the role of DISE in 3 different categories of pediatric OSAS, “conventional”, “disproportional” and “persistent” OSAS. All subjects had preoperative confirmatory polysomnograms. The authors observed that, in otherwise healthy children, DISE changed the surgical plan more frequently in children with “disproportional” and “persistent” OSAS. Additional procedures included functional endoscopic sinus surgery (FESS) for polyp removal and pharyngoplasty for lateral pharyngeal wall collapse correction.
https://www.ncbi.nlm.nih.gov/pubmed/?term=29605338
Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Hinkle J(1), Connolly HV(2), Adams HR(3), Lande MB(4).
Contributors: Denis H Jablonka, Rajeev Subramanyam
Published: J Am Soc Hypertens. 2018 Mar;12(3):204-210. doi: 10.1016/j.jash.2017.12.010. Epub 2018 Jan 3.
In summary, habitual snoring is common in children referred for elevated BP, and those with severe OSA are at higher risk of significantly increased BP.
https://www.ncbi.nlm.nih.gov/pubmed/29373256
Posted in
Clinical Pediatric, Literature Updates
Posted:
June 5, 2018
Authors: Macey PM, Kheirandish-Gozal L, Prasad JP, Ma RA, Kumar R, Philby MF, Gozal D
Contributors: Susana Vacas
Published: Front Neurol. 2018 Jan 22;9:4
Changes in cortical thickness are present in children with OSA and likely indicate disruption to neural developmental processes, including maturational patterns of cortical volume increases and synaptic pruning. Regions with thicker cortices may reflect inflammation or astrocyte activation. Both the thinning and thickening associated with OSA in children may contribute to the cognitive and behavioral dysfunction frequently found in the condition.
https://www.ncbi.nlm.nih.gov/pubmed/29403430
