Authors: Sprecher KE, Koscik RL, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Sager MA, Asthana S, Johnson SC, Benca RM, Bendlin BB.
“Self-report of poor sleep was associated with greater AD-related pathology in cognitively healthy adults at risk for AD. Effective strategies exist for improving sleep; therefore sleep health may be a tractable target for early intervention to attenuate AD pathogenesis.”
Authors: Stokholm MG, Iranzo A, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Møller A, Gaig C, Brooks DJ, Tolosa E, Pavese N.
In patients with idiopathic rapid-eye-movement sleep behaviour disorder, increased microglial activation was detected by PET in the substantia nigra along with reduced dopaminergic function in the putamen.
Authors: Hillman DR, Chung F.
“Patients with sleep-related breathing disorders are more vulnerable to hypoventilation and asphyxia when deeply sedated. Addressing this vulnerability requires a systematic approach to identification of patients and circumstances that magnify this risk, and methods of managing it that seek to reconcile the need for safety with cost-effective use of resources.”
Authors: Verbraecken J, Hedner J, Penzel T.
The methods for screening and the rationale for screening for OSA are reviewed in this study.
Authors: Stranks EK, Crowe SF.
This meta-analysis investigated the cognitive functioning of patients prior to receiving any treatment such as CPAP. A total of 19 studies were included. The authors found statistically significant negative effect sizes in many cognitive domains. The clinical implications, possible causal mechanisms and future implications for research are discussed.
Authors: Subramani Y, Singh M, Wong J, Kushida CA, Malhotra A, Chung F
This review article summarizes the different pathophysiological mechanisms contributing to different endotypes and phenotypes of OSA, and discusses the possible perioperative implications and future directions of research.
Authors: Chung SY, Sylvester MJ, Patel VR, Zaki M, Baredes S, Liu JK, Eloy JA
Patients with OSA undergoing transsphenoidal pituitary surgery have higher rates of pulmonary and airway complications.
Authors: Joyeux-Faure M, Naegelé B, Pépin JL, Tamisier R, Lévy P, Launois SH
This study was conducted in a French outpatient sleep clinic. 36 patients with OSA were randomized to receive either CPAP (n=18) or sham CPAP (n=18) for 6 weeks. The patients underwent an extensive battery of tests evaluating 3 separate memory systems before and after treatment. The authors did not find improvement in memory performance after 6 weeks of treatment.
Authors: Camacho M, Nesbitt NB, Lambert E, Song SA, Chang ET, Liu SY, Kushida CA, Zaghi S.
A systematic review and meta-analysis on laser-assisted uvulopalatoplasty (LAUP) for treatment of obstructive sleep apnea (OSA). LAUP reduced AHI by 32% among all patients; while the LSAT only changed minimally. Individual data demonstrated a success rate of 23%, cure rate of 8%, and worsening of the AHI among 44% of patients.
Authors: Lam EWK, Chung F, Wong J.
This study highlights the importance of screening for sleep-disordered breathing to reduce the risk of postoperative delirium.