Posted in
Basic Research, Literature Updates
Posted:
March 1, 2016
Authors: Marc Cuesta, Philippe Boudreau, Geneviève Dubeau-Laramée, Nicolas Cermakian and Diane B. Boivin
Contributors: Philip Kurien
Published: J Immunol 2016; 196:2466-2475
This work delineates the normal oscillation and responsiveness of circulating monocytes and T lymphocytes in ten human volunteers over circadian time. Under normal circadian parameters, bimodal cytokine secretion was observed with the night peak caused by an increased responsiveness of monocytes, and the day peak corresponding to a higher absolute number of monocytes. T lymphocytes demonstrated an evening peak caused by both higher cell count and responsiveness. When subjected to a night shift schedule (acute circadian disruption) monocyte and T cells circulating phase was not changed but the responsiveness of both cell types was advanced (earlier expression of cytokine) after stimulation. This suggests that acute changes in sleep-wake cycles alter the cell intrinsic responsiveness to stimulation whereas parameters governing circulation may lag behind.
http://www.ncbi.nlm.nih.gov/pubmed/26873990
Posted in
Basic Research, Literature Updates
Posted:
March 1, 2016
Authors: Garcia AJ 3rd, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM.
Contributors: Philip Kurien
Published: Front Neurosci. 2016 Feb 4;10:4.
The preBotzinger complex in rats is a respiratory neuronal network driving inspiratory rhythm. Chronic intermittent hypoxia (as is the case in OSA) causes irregular firing of the preBotzinger complex. Dysrhythmia in the preBotzinger complex loosens the coupling of neuronal transmission with XIIn. Lipid peroxidation is increased in both the preBotzinger complex and XIIn as a result of chronic intermittent hypoxia. Treatment with antioxidant can reverse the instability in neuronal coupling caused by the exposure hypoxia. This work demonstrates the effect of hypoxia on rhythmic breathing in a salient neuronal network and provides a possible therapeutic strategy to re-establish rhythmic neuronal connectivity in this pathway.
http://www.ncbi.nlm.nih.gov/pubmed/26869872
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 1, 2016
Authors: De Luca Canto G, Pachêco-Pereira C, Aydinoz S, Bhattacharjee R, Tan HL, Kheirandish-Gozal L, Flores-Mir C, Gozal D.
Contributors: Kimmo Murto
Published: Pediatrics. 2015 Oct;136(4):702-18.
The most frequent early complications after AT are respiratory compromise and secondary hemorrhage. Based on the current limited evidence, children with OSA appear to have more respiratory complications. Conversely, hemorrhage appears to be more frequent in children without OSA.
http://www.ncbi.nlm.nih.gov/pubmed/26391937
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 1, 2016
Authors: Côté V, Ruiz AG, Perkins J, Sillau S, Friedman NR.
Contributors: Kimmo Murto
Published: Int J Pediatr Otorhinolaryngol. 2015 Jun;79(6):903-8.
In children under 2 years, ethnicity seems to be a predictor of OSA severity. African-American, prematurity, daycare and Down syndrome patients were significantly more represented in our study population. PSG is more likely to be requested for syndromic children.
http://www.ncbi.nlm.nih.gov/pubmed/25912628
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 1, 2016
Authors: Caron CJ, Pluijmers BI, Joosten KF, Mathijssen IM, van der Schroeff MP, Dunaway DJ, Wolvius EB, Koudstaal MJ.
Contributors: Kimmo Murto
Published: Int J Oral Maxillofac Surg. 2015 May;44(5):592-8.
According to the literature, OSA is related to CFM. However, as there have been no prospective studies and few studies have presented objective measurements, no definitive conclusions can be drawn.
http://www.ncbi.nlm.nih.gov/pubmed/25769220
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 1, 2016
Authors: Biggs SN, Nixon GM, Horne RS.
Contributors: Kimmo Murto
Published: Sleep Med Rev. 2014 Dec;18(6):463-75.
Historically, PS has been considered benign, however there is growing evidence that children with PS exhibit cognitive and behavioural deficits equivalent to children with OSA.
http://www.ncbi.nlm.nih.gov/pubmed/25060969
Posted in
Clinical Pediatric, Literature Updates
Posted:
March 1, 2016
Authors: Baijal RG, Bidani SA, Minard CG, Watcha MF.
Contributors: Kimmo Murto
Published: Paediatr Anaesth. 2015 Apr;25(4):392-9.
There was no difference in the incidence of perioperative respiratory complications in children undergoing a T&A following an awake vs deep extubation. Only weight ≤14 kg was associated with increased perioperative respiratory complications.
http://www.ncbi.nlm.nih.gov/pubmed/25370474
Posted in
Clinical Adult, Literature Updates
Posted:
March 1, 2016
Authors: Tan WF1, Miao EY, Jin F, Ma H, Lu HW.
Contributors: Jean Wong, Meghan Kirksey, Kimmo Murto
Published: Reg Anesth Pain Med. 2016 Mar
1.111 elderly male patients undergoing TURP under spinal anesthesia were randomized to no sedation, sedation with midazolam, or sedation with dexmedetomidine. Intraoperative sedation and postoperative sleep were measured using BIS monitor. Sleep efficiency following surgery was found to be lowest in the dexmedetomidine group and sleep duration was approximately 240 minutes longer in the midazolam group compared to those who had been sedated with dexmedetomidine.
http://www.ncbi.nlm.nih.gov/pubmed/26928796
Posted in
Clinical Adult, Literature Updates
Posted:
March 1, 2016
Authors: Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R.
Contributors: Jean Wong, Meghan Kirksey, Kimmo Murto
Published: Nat Commun. 2016 Mar 9;7:10889.
Using the UK Biobank, genome-wide associations were identified linking sleep-time preference (chronotype) to genes and genetic variants related to circadian rhythm and previously uncharacterized pathways that may relate to circadian rhythm and light sensing. Central nervous system, ocular, and fear-response pathways were implicated. Correlations were noted potentially linking the genetics of chronotype to schizophrenia, educational attainment, and BMI.
http://www.ncbi.nlm.nih.gov/pubmed/26955885
Posted in
Clinical Adult, Literature Updates
Posted:
March 1, 2016
Authors: Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK.
Contributors: Jean Wong, Meghan Kirksey, Kimmo Murto
Published: J Clin Sleep Med. J Clin Sleep Med. 2016 Feb 29
697 veterans with suspected sleep disordered breathing were observed for nocturnal arrhythmias during polysomnography. After controlling for age, sex, BMI, and cardiovascular disease, moderate to severe sleep disordered breathing was associated with a two-fold increased risk of nocturnal arrhythmias. Frequency of hypoxic events was positively associated with arrhythmia risk.
http://www.ncbi.nlm.nih.gov/pubmed/26951420
