Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Naylor E, Aillon DV, Barrett BS, Wilson GS, Johnson DA, Johnson DA, Harmon HP, Gabbert S, Petillo PA
Contributors: Kimmo Murto
Published: Sleep. 2012 Sep 1;35(9):1209–22.
This study shows promises of using extracellular lactate concentration as a reliable sleep/wake biomarker.
http://www.ncbi.nlm.nih.gov/pubmed/22942499
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Ueno T, Tomita J, Tanimoto H, Endo K, Ito K, Kume S, Kume K
Contributors: Kimmo Murto
Published: Nat Neurosci. 2012 Oct 14. doi: 10.1038/nn.3238.
The authors set out to map the dopamine pathway that is required for sleep and arousal regulation.
http://www.ncbi.nlm.nih.gov/pubmed/23064381
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Hu FY, Hanna GM, Han W, Mardini F, Thomas SA, Wyner AJ, Kelz MB
Contributors: Kimmo Murto
Published: Anesthesiology. 2012 Nov;117(5):1006–1017.
Using adrenergic-deficient mice the authors showed that adrenergic signaling is essential for normal emergence from general volatile anesthesia. Dexmedetomidine-induced general anesthesia does not depend on inhibition of adrenergic neurotransmission.
http://www.ncbi.nlm.nih.gov/pubmed/23042227
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W
Contributors: Kimmo Murto
Published: J Neurosci. 2012 Sep 19;32(38):13062–75.
This work provides more questions to the role of propofol in entering sleep circuitry. It suggests that a primary function of GABAA receptor-mediated inhibition is to dampen vigilant arousal and it does not appear to influence the loss of consciousness associated with either natural sleep or propofol-induced anesthesia.
http://www.ncbi.nlm.nih.gov/pubmed/22993424
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Vanini G, Lydic R, Baghdoyan HA
Contributors: Kimmo Murto
Published: Sleep. 2012 Oct 1;35(10):1325–34.
Three of the brain regions that comprise the anatomically distributed, sleep-generating network have in common a GABA-mediated, sleep-dependent decrease in the GABA-to-ACh ratio.
http://www.ncbi.nlm.nih.gov/pubmed/23007730
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Maturo SC, Hartnick CJ
Contributors: Kimmo Murto
Published: Adv Otorhinolaryngol. 2012;73:109–11. Epub 2012 Mar 29.
Tonsillectomy and adenoidectomy are an effective surgical treatment of pediatric obstructive sleep apnea; however, up to 20% of these patients can have persistent disease. In this select patient population, the lingual tonsil may be an occult source of obstruction.
http://www.ncbi.nlm.nih.gov/pubmed/22472240
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Yilmaz M, Duzlu M, Catli T, Ustun S, Ceylan A
Contributors: Kimmo Murto
Published: Kaohsiung J Med Sci. 2012 May;28(5):270–2. Epub 2011 Sep 9.
Compared with the cold knife technique, thermal welding was found to be a relatively new and safe technique for tonsillectomy as it results in significantly less postoperative pain and no remarkable blood loss.
http://www.ncbi.nlm.nih.gov/pubmed/22531306
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Gleich SJ, Olson MD, Sprung J, Weingarten TN, Schroeder DR, Warner DO, Flick RP
Published: Paediatr Anaesth. 2012 Jul 9. doi: 10.1111/j.1460–9592.2012.03905.x. [Epub ahead of print].
Severe obesity in children undergoing tonsillectomy is independently associated with an increased risk of perioperative complications.
http://www.ncbi.nlm.nih.gov/pubmed/22776351
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Isaacson G
Contributors: Kimmo Murto
Published: Pediatrics. 2012 Aug;130(2):324–34. Epub 2012 Jul 2.
This article outline these practices as defined in the 2011 American Academy of Otolaryngology-Head and Neck Surgery Foundation clinical practice guideline “Tonsillectomy in Children.
http://www.ncbi.nlm.nih.gov/pubmed/22753552
Posted in
Clinical Pediatric, Literature Updates
Posted:
November 1, 2012
Authors: Acevedo JL, Shah RK, Brietzke SE
Contributors: Kimmo Murto
Published: Otolaryngol Head Neck Surg. 2012 Jun;146(6):871–9. Epub 2012 Mar 6.
Tonsillotomy appears to be a safe technique that may offer some advantages over tonsillectomy in terms of postoperative morbidity, but differences in hemorrhage and dehydration were not evident in high-quality studies.
http://www.ncbi.nlm.nih.gov/pubmed/22394550