Differences in Sleep Patterns and Problems by Race in a Clinical Sample of Black and White Preschoolers

“In contrast to community-based research, Black and White children showed similar sleep patterns. However, there were differences by race in referral questions and diagnoses. Findings suggest the need to consider caregiver perceptions and other sociocultural factors that may contribute to differential rates of presentation for sleep services, as well as potential health disparities in this regard.”


Computed Tomography Characterization and Comparison With Polysomnography for Obstructive Sleep Apnea Evaluation

“An increased RDI appears to be an important variable for predicting the presence of complete obstruction and CCC during OSA. Scanning during apneic episodes, using low-dose volumetric CT combined with portable PSG provided better anatomic and pathologic findings of OSA than did scans performed during the awake state.”


Back to sleep or not: the effect of the supine position on pediatric OSA: Sleeping position in children with OSA

“This study identified that preschool-aged children, whether nonsnoring controls or children with OSA, predominately sleep in the supine position, and OSA was more severe in the supine position. We suggest that to avoid the supine sleep position, positional therapy has the potential to ameliorate OSA severity, and the known cardiovascular consequences.”


Prevalence of obstructive sleep apnoea in acute coronary syndrome: Routine screening in intensive coronary care units

OSA is frequently found in the acute phase of ischaemic heart disease and its presence is associated with more severe ACS and a poorer left ventricle systolic function.


Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort

“Compared to pregnant women without OSA, pregnant women with OSA have a significantly higher risk of pregnancy-specific complications such as gestational hypertensive conditions and gestational diabetes, and rare medical and surgical complications such as cardiomyopathy, pulmonary edema, congestive heart failure, and hysterectomy. OSA diagnosis was also associated with a longer hospital stay and significantly increased odds for admission to the intensive care unit.”


Acute Kynurenine Challenge Disrupts Sleep-Wake Architecture and Impairs Contextual Memory in Adult Rats

Tryptophan metabolism via the kynurenine pathway may represent a key molecular link between sleep loss and cognitive dysfunction.

The results of this study  introduce kynurenine pathway metabolism and formation of metabolite kynurenic acid  as a novel molecular target contributing to sleep disruptions and cognitive impairments.