Author: Bell LM
“The reader is encouraged to read the entire issue that is entitled “Updates on Obstructive Sleep Apnea Syndrome in Children”.
Monthly Archives: July 2017
Polysomnographic Findings after Adenotonsillectomy for Obstructive Sleep Apnea in Obese and Non-Obese Children: A Systemic review and Meta-Analysis
Authors: Lee CH, Hsu WC, Chang WH, Lin MT, Kang KT.
“Meta-analysis of current literature shows T&A offers prominent improvement in a variety of sleep parameters. Improvements in non-obese children exceeded those for obese children. Postoperative residual OSA remained in roughly half of the children, especially those with severe disease and obesity, making additional treatment strategies and/or long-term follow-up highly desirable.”
Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults
Authors: Sprecher KE, Koscik RL, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Sager MA, Asthana S, Johnson SC, Benca RM, Bendlin BB.
“Self-report of poor sleep was associated with greater AD-related pathology in cognitively healthy adults at risk for AD. Effective strategies exist for improving sleep; therefore sleep health may be a tractable target for early intervention to attenuate AD pathogenesis.”
Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
Authors: Stokholm MG, Iranzo A, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Møller A, Gaig C, Brooks DJ, Tolosa E, Pavese N.
In patients with idiopathic rapid-eye-movement sleep behaviour disorder, increased microglial activation was detected by PET in the substantia nigra along with reduced dopaminergic function in the putamen.
Anaesthetic management of sleep-disordered breathing in adults
Authors: Hillman DR, Chung F.
“Patients with sleep-related breathing disorders are more vulnerable to hypoventilation and asphyxia when deeply sedated. Addressing this vulnerability requires a systematic approach to identification of patients and circumstances that magnify this risk, and methods of managing it that seek to reconcile the need for safety with cost-effective use of resources.”
Pre-operative screening for obstructive sleep apnoea
Authors: Verbraecken J, Hedner J, Penzel T.
The methods for screening and the rationale for screening for OSA are reviewed in this study.
The Cognitive Effects of Obstructive Sleep Apnea: An Updated Meta-analysis
Authors: Stranks EK, Crowe SF.
This meta-analysis investigated the cognitive functioning of patients prior to receiving any treatment such as CPAP. A total of 19 studies were included. The authors found statistically significant negative effect sizes in many cognitive domains. The clinical implications, possible causal mechanisms and future implications for research are discussed.
Understanding Phenotypes of Obstructive Sleep Apnea: Applications in Anesthesia, Surgery, and Perioperative Medicine
Authors: Subramani Y, Singh M, Wong J, Kushida CA, Malhotra A, Chung F
This review article summarizes the different pathophysiological mechanisms contributing to different endotypes and phenotypes of OSA, and discusses the possible perioperative implications and future directions of research.
Impact of obstructive sleep apnea in transsphenoidal pituitary surgery: An analysis of inpatient data
Authors: Chung SY, Sylvester MJ, Patel VR, Zaki M, Baredes S, Liu JK, Eloy JA
Patients with OSA undergoing transsphenoidal pituitary surgery have higher rates of pulmonary and airway complications.
https://www.ncbi.nlm.nih.gov/pubmed/28671280
Continuous positive airway pressure treatment impact on memory processes in obstructive sleep apnea patients: a randomized sham-controlled trial
Authors: Joyeux-Faure M, Naegelé B, Pépin JL, Tamisier R, Lévy P, Launois SH
This study was conducted in a French outpatient sleep clinic. 36 patients with OSA were randomized to receive either CPAP (n=18) or sham CPAP (n=18) for 6 weeks. The patients underwent an extensive battery of tests evaluating 3 separate memory systems before and after treatment. The authors did not find improvement in memory performance after 6 weeks of treatment.