Diagnostic Capability of Biological Markers in Assessment of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Kallikrein-1, uromodulin, urocotin-3, and orosomucoid-1 when combined have enough accuracy to be an OSA diagnostic test in children. IL-6 and IL-10 plasma levels have potential to be good biomarkers in identifying or excluding the presence of OSA in adults.

Development and Validation of a Morphologic Obstructive Sleep Apnea Prediction Score: The DES-OSA Score

The authors developed and validated a new clinical score to predict OSA based on morphologic characteristics only. The DES-OSA Score consists of 5 variables: Mallampati score, distance between the thyroid and chin, BMI, neck circumference and sex. These variables were weighted by 1, 2 or 3 points. A score of >5, 6, and 7 were associated with increased probability of mild, moderate or severe OSA.

Impact of Different Nasal Masks on CPAP Therapy for Obstructive Sleep Apnea: A Randomized Comparative Trial

In this randomized controlled trial, the authors compared the impact of different nasal masks for CPAP in patients with newly-diagnosed OSA. Patients were randomized to receive CPAP with ResMed Mirage FX® (MFX) or control mask (Fisher & Paykel Zest®, HC407® or Philips EasyLife®. Mask acceptance rate was higher in the MFX vs. control group. CPAP compliance was higher and nasal mask issue-related Home Care Provider visits were lower in the MFX group. There were less failures due to mask discomfort or unintentional leakage in the MFX group.

CPAP in the Perioperative Setting: Evidence of Support

In this review, the authors examine the evidence for the use of CPAP in the preoperative and postoperative periods in surgical patients with diagnosed and undiagnosed OSA. Barriers to diagnosing and treating OSA in the perioperative setting are examined. Identifying which surgical patients with OSA are at increased risk, and which patients may benefit from CPAP are reviewed.